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Research Summary

The underlying theme of our research is the application of engineering principles and methodology to advance cardiac surgery and physiology. As Director of the Cardiac Surgery Research Laboratory at Brigham and Women's Hospital, I oversee three projects in which he is the principal investigator.

One project investigates the physiology as well as new treatment modalities for heart failure. Currently, our lab focuses on the mechanism and efficacy of a novel treatment for heart failure- ventricular restraint. We invented a new device for ventricular restraint and are using it to apply ventricular restraint in a quantitative manner.

Another general research area is new and emerging technologies for treating valvular disease. Our lab is currently focused on aortic insufficiency (AI), and have recently developed a new device for treating AI secondary to aortic dilatation. We hope to apply this technique in a minimally invasive fashion.

Finally, our third project involves new imaging modalities relevant to cardiac surgery. Specifically, his lab studies real time imaging of myocardial viability and apoptosis secondary to ischemia.

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Equipment & Techniques

Large animal operating room, hemodynamic monitoring equipment

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Funding

NIH RO1 (PI: Chen, 01/2008 - 12/2012) -- "Adjustable and measurable ventricular restraint for heart failure"

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Publications

To access Dr. Frederick Chen's publications, please click here.

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Frederick Chen
MD, PhD

Director of Cardiac Surgery Research Laboratory

Clinical Profile & Contact Information

Research Interests

Heart Failure Ventricular Restraint Device
Aortic Insufficiency Treatment
Cardiac Surgery Imaging Modalities