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Clinical Trials- Partners Clinical Trials: Studies conducted at Brigham and Women's Hospital, Massachusetts General Hospital, Spaulding Rehabilitation Hospital, and McLean Hospital.
Research Areas
Cancer Breast- Mehra Golshan, M.D.: Dr. Golshan has three primary areas of research -- 1) clinical trials of neoadjuvant chemotherapy and targeted therapies for women with breast cancer; 2) ductoscopy in the high-risk woman; and 3) decision making process of women with ductal carcinoma in situ (DCIS)
- Caprice C. Greenberg, M.D., M.P.H. : Her primary research interests are quality of care and patient safety. Through her work at the Center for Outcomes and Policy Research at Dana-Farber Cancer Institute, Dr. Greenberg studies the quality of surgical oncology care, particularly as it relates to breast cancer. Through her collaborations in the Department of Health Policy and Management at Harvard School of Public Health, she works to understand the components of surgical safety and identify ways to improve it.
- J. Dirk Iglehart, M.D.: Dr. Iglehart’s laboratory studies the genetics of breast cancer, focusing on important genes and pathways underlying disease pathogenesis and progression. Recently, the laboratory is interested in global measurements of breast cancer gene expression and genetic alterations. These interests include experience with gene expression arrays and single nucleotide polymorphism (SNP) arrays.
Gastrointestinal- Monica Bertagnolli, M.D.: Dr. Bertagnolli studies intestinal tumor biology. Her laboratory’s goal is to identify markers of early cancer development or cancer progression that can then be modulated to prevent tumors or to treat existing cancers more effectively.
- Ali Tavakkolizadeh, M.D.: Dr. Ali Tavakkolizdeh's current research interests include technology design and testing of Natural Orifice Translumenal Endoscopic Surgery (NOTES) and improvement of glucose homeostasis in diabetes and obesity via better understanding of mechanisms that regulate intestinal absorption.
- Edward Whang, M.D.: The major focus of Dr. Whang's research program is the identification and validation of novel biomarkers and therapeutic targets in gastrointestinal malignancies, especially pancreatic cancer. Other projects focus on the development of strategies for optimizing intestinal regeneration and surgical education.
Lung- Raphael Bueno, M.D.: The primary goal of the his laboratory is to overcome current limitations in the clinical treatment of thoracic malignancies including malignant pleural mesothelioma and lung cancer.
- Gavin Gordon, Ph.D.: His work focuses on translational research of thoracic cancers including, but not limited to, statistical analysis of microarray-based gene expression data, design and optimization of novel bioassays to diagnose and predict clinical outcome in cancer, elucidation of tumor molecular markers using multiple data acquisition platforms, and linking gene discovery with mechanistic studies to improve the design of current treatment regimens in cancer.
- David Sugarbaker, M.D.: His work focuses on five areas: translational research in lung cancer and mesothelioma, multimodality treatment and staging of malignant pleural mesothelioma, neoadjuvant therapy for non-small cell lung cancer, treatment of esophageal cancer, and minimally invasive surgery.
Prostate and TesticularBrian Liu, Ph.D.: His work focuses on understanding the underlying mechanisms behind prostate cancer, as well as searching for new biomarkers and drug targets.
Michael O' Leary, M.D., M.P.H.: His major focus has been on the development and validation of hard measures of subjective outcomes in Urologic disease. His most recent endeavor is a NIH supported study on Proteomics Approaches to Benign Prostatic Hyperplasia, the overall goal of which is to identify potential biomarkers, which can distinguish between BPH from prostate cancer and normal prostate.
- Jerome Richie, M.D.: His major research interests include testicular cancer, prostate cancer, and urology related malignancies
- Graeme Steele, M.D.: His main research interests include the role of heat therapy in the management of symptomatic Benign Prostatic Hyperplasia, the role of urodynamic evaluation in symptomatic BPH, Ileal neobladder following cystoprostatectomy in bilharzial bladder cancer, urinary incontinence following radical prostatectomy, and the epidemiology of testis cancer.
Digestive System- Stanley Ashley, M.D.: Dr. Ashley develops new treatments for surgical disorders of the gastrointestinal tract. Emphasis is placed on maximizing synergy between clinical and basic research.
- David Soybel, M.D.: Dr. Soybel's research interests focus on epithelial function in the setting of acute injury and inflammation. Most recently, Dr. Soybel and his collaborators are exploring the interactions between epithelia and activated neutrophils during sustained inflammation such as that observed in H. pylori-induced gastritis and Inflammatory Bowel Diseases.
- Ali Tavakkolizadeh, M.D.: Dr. Ali Tavakkolizdeh's current research interests include technology design and testing of Natural Orifice Translumenal Endoscopic Surgery (NOTES) and improvement of glucose homeostasis in diabetes and obesity via better understanding of mechanisms that regulate intestinal absorption.
- Edward Whang, M.D.: The major focus of Dr. Whang's research program is the identification and validation of novel biomarkers and therapeutic targets in gastrointestinal malignancies, especially pancreatic cancer. Other projects focus on the development of strategies for optimizing intestinal regeneration and surgical education.
Health Services Outcome- Atul Gawande, M.D., M.P.H.: His goal has been to make a major contribution to knowledge, understanding, and individual lives through both academic and clinical work at the intersection of surgery and public health. More recently, his work has expanded to address questions in global health--in particular, how to meet the growing demand for care for surgical diseases in poorer countries.
- Caprice C. Greenberg, M.D., M.P.H. : Her primary research interests are quality of care and patient safety. Through her work at the Center for Outcomes and Policy Research at Dana-Farber Cancer Institute, Dr. Greenberg studies the quality of surgical oncology care, particularly as it relates to breast cancer. Through her collaborations in the Department of Health Policy and Management at Harvard School of Public Health, she works to understand the components of surgical safety and identify ways to improve it.
- Selwyn O. Rogers, Jr., M.D., M.P.H.: His primary research interest is assessing clinical outcomes in human populations. Using epidemiological and health services research methods, areas of investigation include characterizing outcomes from surgical procedures and examining variations in outcomes of different patient populations. Future investigation will focus on improving the quality of care and processes of care.
Heart & Vascular- Frederick Chen, M.D., Ph.D.: Dr. Chen applies engineering principles and methodology to advance cardiac surgery and physiology research. His research areas include finding new treatment modalities for heart failure, emerging technologies for treating valvular disease, and imaging modalities relevant to cardiac surgery.
- Michael Davidson, M.D.: Dr. Davidson is researching on techniques for heart valve repair, a procedure that most often requires open-heart surgery. For some patients who are elderly or have other health problems, open-heart procedures carry serious risk. Dr. Davidson’s work to develop percutaneous (catheter-based), less-invasive approaches for valve disease will offer an alternative.
- Aldebaran Hofer, Ph.D.: The research focus in her lab is on signal transduction, with particular emphasis on calcium signaling. She uses fluorescence imaging techniques to monitor the movements of calcium and other second messengers inside single living cells. Recently she has begun to explore the role of extracellular calcium as a signaling molecule.
- Raouf A. Khalil, M.D., Ph.D.: The main areas of his research are smooth muscle physiology and pharmacology; pathophysiology of hypertension, restenosis and coronary artery disease; vascular smooth muscle contractility and growth; Ca2+-dependent and Ca2+-independent mechanisms of cell activation; Ca2+ homeostasis in living cells; signal transduction, G proteins, protein kinase C and kinase cascades; fluorescent probes, immunofluorescence and immunocytochemistry; and digital imaging microscopy and confocal microscopy.
- Louis Nguyen, M.D., M.B.A., M.P.H.: Dr. Nguyen studies the effects of diabetes, insulin resistnace, and inflammation on outcomes of infrainguinal percutaneous peripheral interventions for intermitten claudication.
Immune System- James Lederer, M.D. and John Mannick, M.D.: Their laboratory is devoted to the study of interactions between the innate and adaptive immune systems involved in initiating both the SIRS and CARS responses to injury.
- Steven Mentzer, M.D.: His laboratory uses a systems biology approach to investigate lymphocytic inflammation. The goal of systems biology is to identify the functional rules of interactions between proteins and cells. In the context of lymphocytic inflammation, he applies a systems biology approach to the study of lymphocytic inflammation in the three portals of entry: skin, gut and lung.
Lung- Raphael Bueno, M.D.: The primary goal of the his laboratory is to overcome current limitations in the clinical treatment of thoracic malignancies including malignant pleural mesothelioma and lung cancer.
- Yolonda Colson, M.D., Ph.D.: Her research interests include transplantation immunology and tolerance induction, bone marrow chimerism, innate and adaptive immunity, and lung cancer.
- Gavin Gordon, Ph.D.: His work focuses on translational research of thoracic cancers including, but not limited to, statistical analysis of microarray-based gene expression data, design and optimization of novel bioassays to diagnose and predict clinical outcome in cancer, elucidation of tumor molecular markers using multiple data acquisition platforms, and linking gene discovery with mechanistic studies to improve the design of current treatment regimens in cancer.
- Michael Jaklitsch, M.D.: His research interests include database development and clinical outcome measurements in thoracic surgery and lung cancer in the elderly.
- Steven Mentzer, M.D.: His laboratory uses a systems biology approach to investigate lymphocytic inflammation. The goal of systems biology is to identify the functional rules of interactions between proteins and cells. In the context of lymphocytic inflammation, he applies a systems biology approach to the study of lymphocytic inflammation in the three portals of entry: skin, gut and lung.
- David Sugarbaker, M.D.: His work focuses on five areas: translational research in lung cancer and mesothelioma, multimodality treatment and staging of malignant pleural mesothelioma, neoadjuvant therapy for non-small cell lung cancer, treatment of esophageal cancer, and minimally invasive surgery.
Men's HealthBrian Liu, Ph.D.: His work focuses on understanding the underlying mechanisms behind prostate cancer, as well as searching for new biomarkers and drug targets.
Michael O' Leary, M.D., M.P.H.: His major focus has been on the development and validation of hard measures of subjective outcomes in Urologic disease. His most recent endeavor is a NIH supported study on Proteomics Approaches to Benign Prostatic Hyperplasia, the overall goal of which is to identify potential biomarkers, which can distinguish between BPH from prostate cancer and normal prostate.
Jerome Richie, M.D.: His major research interests include testicular cancer, prostate cancer, and urology related malignancies
Graeme Steele, M.D.: His main research interests include the role of heat therapy in the management of symptomatic Benign Prostatic Hyperplasia, the role of urodynamic evaluation in symptomatic BPH, Ileal neobladder following cystoprostatectomy in bilharzial bladder cancer, urinary incontinence following radical prostatectomy, and the epidemiology of testis cancer.
Oral HealthStephen T. Sonis, D.M.D.: His research focuses on studies that investigate the general and molecular epidemiology, mechansims, burden of illness, and novel interventions associated with mucosal barrier injury.
Organ TransplantYolonda Colson, M.D., Ph.D.: Her research interests include transplantation immunology and tolerance induction, bone marrow chimerism, innate and adaptive immunity, and lung cancer.
Stefan Tullius, M.D., Ph.D.: His research currently focuses on the correlation between innate and adaptive immunity, effects of increasing donor and recipient age, and criteria definition for clinical tolerance induction.
Trauma, Burn, and Critical CareElof Eriksson, M.D., Ph.D.: His research lab broadly aims at creating better treatment for both acute and chronic wounds. By combining the most advanced methods for wound treatment with genetic manipulation of the cells in the wound. Their work provides new insight into how wounds heal. They are also using gene therapy as a powerful tool to stimulate healing or inhibit scar formation. The overall objective of his research program is to gain a better understanding of the molecular and cellular effects and interactions on wound repair in normal and impaired wounds. Dennis P. Orgill, M.D., Ph.D.: His lab is a basic science research group that is dedicated to furthering the understanding of wound and tissue healing with an emphasis on clinical applications for medicine.
Francis D. Moore, Jr., M.D.: Dr. Moore's Lab focuses on the advancement of the care of the traumatized by a novel conceptual formulation of their disease process, and thereby help not just the injured but also critically ill patients as a whole. James Lederer, M.D. and John Mannick, M.D.: Their laboratory is devoted to the study of interactions between the innate and adaptive immune systems involved in initiating both the SIRS and CARS responses to injury.
Bohdan Pomahac, M.D.: His research is focused on wound healing via gene therapy and healing environment changes. Dr. Pomahac collaborated with the Department of Dermatology, Children’s Hospital Boston to study the effects of adhesion molecules and growth factors on wound healing.
Feng Yao, Ph.D.: His major research interests are gene regulation, HSV vaccine, HSV-1 viral vector based in vivo gene transfer and cancer therapy, wound healing and tissue regeneration. The laboratory has established a new gene switch technology with which one can turn on and off gene expression at will using tetracycline or its derivatives. This technology is currently licensed by Invitrogen Inc. (The T-RExTM System) and can be used for studying gene function in cell biology, virology and has potential application in future human gene therapy.
Selwyn O. Rogers, Jr., M.D., M.P.H.: His primary research interest is assessing clinical outcomes in human populations. Using epidemiological and health services research methods, areas of investigation include characterizing outcomes from surgical procedures and examining variations in outcomes of different patient populations. Future investigation will focus on improving the quality of care and processes of care.
Vision / Aging Research- Leo Chylack, Jr., M.D.: Dr. Chylack focuses on mechanisms of normal vision and blinding diseases. His laboratory's primary disease-related focus is the study age-related and other forms of lens opacification and cataract.
Lee E. Goldstein, M.D., Ph.D,: Dr. Goldstein's research focuses on understanding the role of abnormal protein aggregation in chronic degenerative disorders of aging. The work in his laboratory concentrates on Alzheimer's disease, age-related cataracts, and other diseases that involve pathogenic protein aggregation. Todd Horowitz, Ph.D.: His primary research interests are in attention, especially visual search behavior, and circadian effects on cognition. - Jack Liang, Ph.D.: His main research interest has centered on the biochemical and biophysical properties of lens proteins (mainly α-, β- and γ-crystallins) and the changes in their properties during age-related cataractogenesis (ARC).
- Jeremy Wolfe, Ph.D.: His lab does basic research in visual selective attention.
Women's HealthJ. Dirk Iglehart, M.D.: Dr. Iglehart’s laboratory studies the genetics of breast cancer, focusing on important genes and pathways underlying disease pathogenesis and progression. Recently, the laboratory is interested in global measurements of breast cancer gene expression and genetic alterations. These interests include experience with gene expression arrays and single nucleotide polymorphism (SNP) arrays.
Wound and Tissue HealingElof Eriksson, M.D., Ph.D.: His research lab broadly aims at creating better treatment for both acute and chronic wounds. By combining the most advanced methods for wound treatment with genetic manipulation of the cells in the wound. Their work provides new insight into how wounds heal. They are also using gene therapy as a powerful tool to stimulate healing or inhibit scar formation. The overall objective of his research program is to gain a better understanding of the molecular and cellular effects and interactions on wound repair in normal and impaired wounds.
Dennis P. Orgill, M.D., Ph.D.: His lab is a basic science research group that is dedicated to furthering the understanding of wound and tissue healing with an emphasis on clinical applications for medicine.
Bohdan Pomahac, M.D.: His research is focused on wound healing via gene therapy and healing environment changes. Dr. Pomahac collaborated with the Department of Dermatology, Children’s Hospital Boston to study the effects of adhesion molecules and growth factors on wound healing.
Feng Yao, Ph.D.: His major research interests are gene regulation, HSV vaccine, HSV-1 viral vector based in vivo gene transfer and cancer therapy, wound healing and tissue regeneration. The laboratory has established a new gene switch technology with which one can turn on and off gene expression at will using tetracycline or its derivatives. This technology is currently licensed by Invitrogen Inc. (The T-RExTM System) and can be used for studying gene function in cell biology, virology and has potential application in future human gene therapy.
News & Events- Harvard Health Publications: Access to health information from Harvard Medical School's books and newsletters, written for the general public.
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 Send Feedback to: Department of Surgery at bwhsurgery@partners.org
This page was last modified on 8/26/2008
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