Selected Maas Lab Publications

Maas RL, Brash AR, Oates JA. A second pathway of leukotriene biosynthesis in porcine leukocytes. Proc Natl Acad Sci USA 1981; 78:5523‑27. PubMed Link

Robertson RM, Robertson D, Roberts LJ II, Maas RL, Fitzgerald GA, Friesinger GC, Oates JA. Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials. N Engl J Med 1981; 304:998‑1003. PubMed Link

FitzGerald GA, Maas RL, Stein R, Oates JA, Roberts LJ II. Intravenous prostacyclin in thrombotic thrombocytopenic purpura. Ann Intern Med 1981; 95:319‑22. PubMed Link

Rand T, Turk J, Maas RL, Colley D. Involvement of the lipoxygenase pathway in the response to the lymphokine eosinophil stimulation promoter. J Immunol 1982; 129:1239‑44. PubMed Link

Turk J, Maas RL, Brash AR, Roberts LJ II, Oates JA. Arachidonic acid 15‑lipoxygenase products from human eosinophils. J Biol Chem 1982; 257:7068‑76. PubMed Link

Maas RL, Ingram CD, Taber DF, Oates JA, Brash AR. Stereospecific removal of the DR hydrogen atom at the 10‑carbon of arachidonic acid in the biosynthesis of leukotriene A4 by human leukocytes. J Biol Chem 1982; 257:13515‑19. PubMed Link

Maas RL, Turk J, Oates JA, Brash AR. Formation of a novel dihydroxy acid from arachidonic acid by lipoxygenase catalyzed double oxygenation in rat mononuclear cells and human leukocytes. J Biol Chem 1982; 257:7056-67. PubMed Link

Maas RL, Brash AR. Evidence for a lipoxygenase mechanism in the biosynthesis of epoxide and dihydroxy leukotrienes from 15(S)‑hydroperoxy-icosatetraenoic acid by human platelets and porcine leukocytes. Proc Natl Acad Sci USA 1983; 80:2882‑88. PubMed Link

FitzGerald GA, Oates JA, Hawiger J, Maas RL, Roberts LJ II, Lawson J, Brash AR. Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. J Clin Invest 1983; 71:676‑688. PubMed Link

Turk J, Rand TH, Maas RL, Lawson JA, Brash AR, Roberts LJ II, Colley DG, Oates JA. Identification of lipoxygenase products from arachidonic acid metabolism in stimulated murine eosinophils. Biochim Biophys Acta 1983; 750:78‑90. PubMed Link

Brash AR, Maas RL, Oates JA. On the mechanism of biosynthesis of 5‑ and 15‑series leukotrienes. J Allergy Clin Immunol 1984; 74:316‑23. PubMed Link

Brash AR, Porter AT, Maas RL. Investigation of the selectivity of hydrogen abstraction in the nonenzymatic formation of hydroxyeicosatetraenoic acids and leukotrienes by autooxidation. J Biol Chem 1985; 260:4217-28. PubMed Link

Maas RL, Ingram CD, Porter AT, Oates JA, Taber DF, Brash AR. Investigation of the chemical conversion of hydroperoxyeicosatetraenoate (HPETE) to leukotriene epoxide using stereospecifically labeled arachidonic acid: comparison with the enzymatic reaction. J Biol Chem 1985; 260:4210‑16. PubMed Link

Brash AR, Ingram CD, Maas RL. A secondary isotope effect in the lipoxygenase reaction. Biochim Biophys Acta 1986; 875:256‑61. PubMed Link

Maas RL, Zeller R, Woychik RP, Vogt TF, Leder P. Disruption of formin‑encoding transcripts in two mutant Limb-Deformity alleles. Nature 1990; 346:853-55. PubMed Link

Woychik RP, Maas RL, Zeller R, Vogt TF, Leder P. "Formins": proteins deduced from the alternative transcripts of the Limb-Deformity gene. Nature 1990; 346:850-53. PubMed Link

Maas RL, Jepeal LI, Elfering SL, Holcombe RF, Morton CC, Eddy RL, Byers MG, Shows TB, Leder P. Chromosomal location and RFLPs of a human gene homologous to the formin gene residing at the murine Limb-Deformity locus. Am J Hum Genet 1991; 48:687-95. PubMed Link

Glaser T, Walton DS, Maas RL. Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene. Nat Genet 1992; 2:232-39. PubMed Link

Glaser T, Ton CCT, Mueller R, Petzel-Erler ML, Oliver C, Nevin NC, Housman DE, Maas RL. Exclusion of PAX6 gene mutations in Gillespie Syndrome (partial aniridia, cerebellar ataxia and mental retardation). Genomics 1994; 19:145-48. PubMed Link

Barnett JV, Moustakas A, Lin W, Wang X-F, Lin HY, Galper JB, Maas RL. Cloning and developmental expression of chick type II and type III TGFß2 receptors. Dev Dyn 1994; 199:12-27. PubMed Link

Maas R, Elfering S, Glaser T, Jepeal L. Deficient outgrowth of the ureteric bud underlies the renal agenesis phenotype in mice manifesting the limb deformity (ld) mutation. Dev Dyn 1994; 199:214-28. PubMed Link

Epstein J, Cai J, Glaser T, Jepeal L, Maas RL. Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes. J Biol Chem 1994; 269:8355-61. PubMed Link

Satokata I, Maas R. Msx-1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Nat Genet 1994; 6:348-55. PubMed Link

Glaser T, Jepeal L, Edwards JG, Young SR, Favor J, Maas RL. PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects. Nat Genet 1994; 7:463-71. PubMed Link

Epstein JA, Glaser T, Cai J, Jepeal L, Walton DS, Maas RL. Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing. Genes Dev 1994; 8:2022-34. PubMed Link

Benson GV, Nguyen T-H, Maas RL. The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of abdominal B-like genes. Mol Cell Biol 1995; 15:1591-1601. PubMed Link

Satokata I, Benson GV, Maas RL. Sexually dimorphic sterility phenotype in Hoxa10 deficient mice. Nature 1995; 374:460-63. PubMed Link

Epstein JA, Lam P, Jepeal L, Maas RL, Shapiro, DN. Pax3 inhibits myogenic differentiation of cultured myoblast cells. J Biol Chem 1995; 270:11719-22. PubMed Link

Epstein JA, Shapiro DN, Cheng J, Lam PY, Maas RL. Pax3 modulates expression of the c-MET receptor during limb muscle development. Proc Natl Acad Sci USA 1996; 93:4213-18. PubMed Link

Benson GV, Lim H, Paria BC, Satokata I, Dey SK, Maas RL. Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression. Development 1996; 122:2687-96. PubMed Link

Chen YP, Bei M, Woo I, Satokata I, Maas RL. Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development 1996; 122:3035-44. PubMed Link

Phippard DJ, Weber-Hall SJ, Sharpe PT, Naylor MS, Jayatalake H, Maas RL, Woo I, Roberts-Clark D, Francis-West PH, Liu Y-H, Maxson R, Hill RE, Dale TC. Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development. Development 1996; 122:2729-37. PubMed Link

Xu P-X, Woo I, Her H, Beier DR, Maas RL. Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in cranial placodes. Development 1997; 124:219-31. PubMed Link

Xu P-X, Cheng J, Epstein JA, Maas RL. Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function. Proc Natl Acad Sci USA 1997; 94:11974-79. PubMed Link

Sharon-Friling R, Richardson J, Sperbeck S, Lee D, Rauchman M, Maas RL, Swaroop A, Wistow, G. Lens-specific gene recruitment of x-crystallin through Pax6, Nrl-Maf, and brain supressor sites. Mol Cell Biol 1998; 18:2067-76. PubMed Link

Ma L, Benson GV, Lim H, Dey SK, Maas RL. Abdominal B (AbdB) Hoxa genes: regulation in adult uterus by estrogen and progesterone and repression in Mullerian duct by the synthetic estrogen diethylstilbestrol (DES). Dev Biol 1998; 197:141-54. PubMed Link

Bei M, Maas R. BMPs and FGFs induce distinct Msx1-dependent signaling pathways in early tooth morphogenesis. Development 1998; 125:4325-33. PubMed Link

Jain MK, Kashiki S, Hsieh C-M, Layne MD, Yet S-F, Sibinga NE, Chin MT, Feinberg MW, Woo I, Maas RL, Haber E, Lee M-E. Embryonic expression suggests an important role for CRP22/SmLIM in the developing cardiovascular system. Circulation Research 1998; 83:980-85. PubMed Link

Xu P-X, Zhang X, Heaney S, Yoon A, Michelson A, Maas RL. Regulation of Pax6 is conserved between mice and flies. Development 1999; 126:383-95. PubMed Link

Podlasek CA, Seo RM, Clemens JQ, Ma L, Maas RL, Bushman W. Hoxa-10 deficient male mice exhibit abnormal development of the accessory sex organs. Dev Dyn 1999; 214:1-12. PubMed Link

Wawersik S, Purcell P, Rauchman M, Dudley AT, Robertson EJ, Maas R. BMP7 is required for murine lens placode development. Dev Biol 1999; 207:176-88. PubMed Link

Xu HE, Rould MA, Xu W, Epstein JA, Maas RL, Pabo CO. Crystal structure of the human PAX6 paired domain-DNA complex reveals specific roles for the linker region and C-terminal subdomain in DNA binding. Genes Dev 1999; 13:1263-75. PubMed Link

Lim H, Ma L, Ma W-G, Maas RL, Dey SK. Hoxa-10 regulates uterine stromal cell responsiveness to progesterone during implantation and decidualization in the mouse. Mol Endocrinol 1999; 13:1005-17. PubMed Link

Xu P-X, Adams J, Peters H, Brown MC, Heaney S, Maas R. Eya1-deficient mice lack ears and kidneys and exhibit abnormal apoptosis of organ primordia. Nat Genet 1999; 23:113-17. PubMed Link

Kuratani S, Satokata I, Blum M, Komatsu Y, Haraguchi R, Nakamura S, Suzuki K, Kosai K, Maas R, Yamada G. Middle ear defects associated with the double knock out mutation of murine goosecoid and Msx1 genes. Cell Mol Biol 1999; 45:589-99. PubMed Link

Peters H, Wilm B, Sakai N, Imai K, Maas R, Balling R. Pax1 and Pax9 synergistically regulate vertebral column development. Development 1999; 126:5399-5408. PubMed Link

Satokata I, Ma L, Ohshima O, Bei M, Woo I, Nishizawa K, Maeda T, Takano Y, Uchiyama M, Heaney S, Peters H, Tang Z, Maxson R, Maas R. Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nat Genet 2000; 24:391-95. PubMed Link

Sivak J, Mohan R, Rinehart WB, Xu P-X, Maas RL, Fini ME. Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B. Dev Biol 2000; 222:41-54. PubMed Link

Bei M, Kratochwil K, Maas R. BMP4 rescues a non-cell autonomous function of Msx1 in tooth development. Development 2000; 127:4711-18. PubMed Link

Chen YP, Zhang Y, Jiang T-X, Barlow AJ, St. Amand TR, Hu Y, Francis-West P, Chuong C-M, Maas RL. Conservation of early odontogenic signaling pathways in Aves. Proc Natl Acad Sci USA 2000; 97:10044-49. PubMed Link

Branford WW, Benson GV, Ma L, Maas RL, Potter SS. Characterization of Hoxa-10/Hoxa-11 transheterozygotes reveals functional redundancy and regulatory interactions. Dev Biol 2000; 224:373-87. PubMed Link

Dassule H, Lewis P, Bei M, Maas R, McMahon AP. Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 2000; 127:4775-85. PubMed Link

Davis RJ, Shen W, Sandler YI, Amou M, Purcell P, Maas R, Ou C-N, Vogel H, Beaudet AL, Mardon G. Dach1 mutant mice bear no gross abnormalities in eye, limb and brain development and exhibit post-natal lethality. Mol Cell Biol 2001; 21:1484-90. PubMed Link

Jumlongras D, Bei M, Felbor U, Maas RL, Seidman JG, Olsen BR. A nonsense mutation in MSX1 causes tooth and nail (Witkop) syndrome. Am J Hum Genet 2001; 69:67-74. PubMed Link

Couse JF, Dixon D, Yates M, Moore A, Ma L, Maas R, Korach K. Estrogen receptor-a knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract. Dev Biol 2001; 238:224-38. PubMed Link

Kwang SJ, Brugger SM, Lazik A, Merrill AE, Wu L-Y, Liu Y-H, Ishii M, Rauchman M, Sangiorgi F, Maas R, Maxson Jr RE. Msx2 is an immediate downstream effector of Pax3 in the development of the murine cardiac neural crest. Development 2002; 129:527-538. PubMed Link

Xu P-X, Zheng W, Laclef C, Maire P, Maas R, Peters H, Xu X. Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. Development 2002; 129: 3033-44. PubMed Link

Zhang X, Friedman A, Heaney S, Purcell P, Maas RL. Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis. Genes Dev 2002; 16:2097-2107. PubMed Link

Gritli-Linde A, Bei M, Maas R, Zhang XM, Linde A, McMahon AP. Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development 2002; 129:5323-37. PubMed Link

Leader B, Lim H, Carabatsos MJ, Harrington A, Ecsedy J, Pellman D, Maas R, Leder P. Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes. Nat Cell Bio 2002; 4:921-8. PubMed Link

Ma L, Liu J, Wu T, Plikus M, Jiang T-X, Bi Q, Liu Y-H, Muller-Rover S, Peters H, Sundberg JP, Maxson R, Maas RL, Chuong C-M. “Cyclic alopecia” in Msx2 mutants: defects in hair cycling and hair shaft differentiation. Development 2003; 130:379-89. PubMed Link

Zhang X, Heaney S, Maas RL. Cre-loxp fate-mapping of Pax6 enhancer active retinal and pancreatic progenitors. Genesis 2003; 35:22-30. PubMed Link

Mylene WM, Yao MW, Lim H, Schust D, Choe S, Farago A, Ding Y, Michaud S, Church G, Maas RL. Gene expression profiling reveals progestrone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the pre-implantation uterus. Mol Endocrinol 2003; 17:610-27. PubMed Link

Han J, Yoshihiro I, Yeo JY, Sucov H, Maas R, Chai Y. Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19^INK4d expression during odontogenesis. Dev Biol 2003; 261:183-96. PubMed Link

Li X, Oghi KA, Zhang J, Krones A, Bush KT, Nigam SK, Aggarwal AK, Maas R, Rose DW, Rosenfeld MG. Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature2003, 426: 247-54. PubMed Link

Jumlongras D, Lin JY, Chapra A, Seidman CE, Seidman JG, Maas RL, Olsen BR. A novel missense mutation in the paired domain of PAX9 causes non-syndromic oligodontia. Hum Genet 2004; 114:242-9. PubMed Link

Purcell P, Oliver G, Mardon G, Donner A, Maas R. Pax6-dependence on Six3, Eval and Dach1 expression during lens and nasal placode induction. Gene Exp Patterns 6 2005; 110-118. PubMed Link

Alkuraya, F, Saadi I, Lund J, Turbe-Doan A, Morton C, Maas R. SUMO1 Haploinsufficiency Leads to Cleft Lip and Palate. Science 2006; 313:1751. PubMed Link

Kuraguchi M, Wang X-P, Bronson R, Rothenberg R, Ohene-Baah NY, Lund J, Kucherlapati M, Maas R, Kucherlapati R. Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PloS Genetics 2006; 2:1362-74. PubMed Link

Donner A, Ko F, Episkopou V, Maas RL. Pax6 is misexpressed in Sox1 null lens fiber cells. Gene Exp Patterns 2007; 7:606-613 PubMed Link

Zhang X, Rowan S, Yue Y, Heaney S, Pan Y, Brendolan A, Selleri L, Maas RL. Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Dev Biol 2006; 300:748-57. PubMed Link

Donner AL, Episkopou V, Maas RL. Sox2 and Pou2f1 interact to control lens and olfactory placode development. Dev Biol 2007; 303:784-799. PubMed Link

Nolte C, Rastegar M, Amores A, Bouchard M, Grote D, Maas R, Nagy Kovacs E, Postlethwait J, Rambaldi I, Rowan S, Yan Y, Zhang F, Featherstone M. Stereospecificity and PAX6 function direct Hoxd4 neural enhancer activity along the antro-posterior axis. Dev Biol 2006; 299:582-93. PubMed Link

Leach NT, Sun Y, Michaud S, Zheng Y, Ligon KL, Ligon AH, Korf BR, Lu W, Harris DJ, Gusella JF, Maas RL, Quade BJ, Cole AJ, Kelz MB, Morton CC. Disruption of diacylglycerol kinase delta in association with seizures and vascular abnormalities. Am J Hum Genet 2007; 80(4):792-9. PubMed Link

Lu W, van Eerde AM, Fan X, Quintero-Rivera F, Kulkarni S, Ferguson HL, Kim H, Fan Y, Xi Q, Li QG, Sanlaville D, Andrews W, Sundaresan V, Bi W, Yan J, Giltay JC, Wijmenga C, de Jong TPV, Feather S, Woolf A, Rao Y, Lupski JR, Eccles MR, Quade BJ, Gusella JF, Morton CC, Maas RL. Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. Am J Hum Genet 2007; 80(4):616-32. PubMed Link

Lu W, Quintero-Rivera F, Fan Y, Alkuraya F, Donovan DJ, Xi Q, Turbe-Doan A, Li QG, Campbell CG, Shanske AL, Sherr E, Ahmad A, Peters R, Rilliet B, Parvex P, Bassuk AG, Harris DJ, Ferguson H, Kelly C, Walsh C, Gronostajski RM, Higgins A, Ligon AH, Quade BJ, Morton CC, Gusella JF, Maas RL. NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects. PLoS Genetics 3(5): e80, Epub May 25, 2007 PubMed Link

Wang XP, Suomalainen M, Felszeghy S, Zelarayan LC, Alonso MT, Plikus MV, Maas RL, Chuong CM, Schimmang T, Thesleff I. An Integrated gene regulatory network controls stem cell proliferation in teeth. PLoS Biol. 2007 Jun; 5(6):e159. Pubmed Link

Williamson RE, Darrow KN, Michaud S, Jacobs JS, Jones MC, Eberl DF, Maas RL, Liberman MC, Morton CC. Methylthioadenosine phosphorylase (MTAP) in hearing: gene disruption by chromosomal rearrangement in a hearing impaired individual and model organism analysis. Am J Med Genet A. 2007 Jul 15; 143(14):1630-9. Pubmed Link

Han J, Ishii M, Bringas P Jr, Maas RL, Maxson RE Jr, Chai Y. Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development. Mech Dev. 2007 Sep-Oct; 124(9-10):729-45. Pubmed Link

Nishimura W, Rowan S, Salameh T, Maas RL, Bonner-Weir S, Sell SM, Sharma A. Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol. 2008 Feb 15; 314(2):443-56. Pubmed Link

Higgins AW, Alkuraya FS, Bosco AF, Bruns GAP, Donovan DJ, Eisenman R, Fan Y, Farra CG, Ferguson HL, Gusella JF, Harris DJ, Herrick SR, Kelly C, Kim HG, Kishikawa S, Kocher KM, Korf BR, Kulkarni, S, Leach NT, Lemyre E, Lewis J, Ligon AH, Lu W, Maas RL, MacDonald ME, Moore SDP, Peters RE, Quade BJ, Quintero-Rivera F, Saadi I, Shen Y, Shendure J, Williamson RE, Morton CC. Characterization of Apparently Balanced Chromosomal Rearrangements from the Developmental Genome Anatomy Project. Am J Hum Genet 2008 Mar;82(3):712-22. Pubmed Link