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Selected Cichowski Lab Publications
Corvera, S., Baretels, J., Capocasale, R., Cichowski, K., and Moore, J. Increased assembly of clathrin occurs in response to mitogenic activation of murine lymphocytes. J Biol Chem 1989; 264:12568-12572. PubMed Link Cichowski, K., McCormick, F., and Brugge, J.S. p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets. J Biol Chem 1992; 267:5025-5029. PubMed Link Vassallo, R.R., Jr., Kieber-Emmons, T., Cichowski, K., and Brass, L.F. Structure/function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J Biol Chem 1992; 267:6081-6085. PubMed Link Brass, L.F., Vassallo, R.R., Jr., Belmonte, E., Ahuja, M., Cichowski, K., and Hoxie, J.A. Structure and function of the human thrombin receptor:studies using monoclonal antibodies against a defined epitope within the receptor N-terminus. J Biol Chem 1992; 267:13795-13798. PubMed Link Cichowski, K., Brugge, J.S., and Brass, L.F. Thrombin receptor activation and integrin engagement stimulate tyrosine phosphorylation of the proto-oncogene product, p95vav, in platelets. J Biol Chem 1996; 271:7544-7550. PubMed Link Johnson, L., Greenbaum, D., Cichowski, K., Mercer, K., Murphy, E., Schmitt, E., Bronson, R.T., Umanoff, H., Edelmann, W., Kucherlapati, R., Jacks, T. K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes Dev 1997;19:2468-2481. PubMed Link Cichowski, K., Orsini, M.J., Brass, L.F. PAR1 activation initiates integrin engagement and outside-in signalling in megakaryoblastic CHRF-288 cells. Biochim Biophys Acta 1999; 1450:265-276. PubMed Link Cichowski, K., Shih, T.S., Schmitt, E., Santiago, S., Reilly, K., McClaughlin, M.E., Bronson, R.T., Jacks, T. Mouse models of tumor development in neurofibromatosis type 1. Science 1999; 286: 2172-2176. PubMed Link Cichowski, K., Santiago S., Jardim, M., Johnson, B.W., Jacks, T. Dynamic regulation of Ras pathway via proteolysis of the NF1 tumor suppressor. Genes Dev 2003; 17:449-454. PubMed Link Stemmer-Rachamimov AO, Louis DN, Nielsen GP, Antonescu CR, Borowsky AD, Bronson RT, Burns DK, Cervera P, McLaughlin ME, Reifenberger G, Schmale MC, MacCollin M, Chao RC, Cichowski K, Kalamarides M, Messerli SM, McClatchey AI, Niwa-Kawakita M, Ratner N, Reilly KM, Zhu Y, Giovannini M. Comparitive pathology of nerve sheath tumors in mouse models and humans. Cancer Res. 2004 May 15; 64 (10):3718-24. PubMed Link Engelman JA, Janne PA, Mermel C, Pearlberg J, Mukohara T, Fleet C, Cichowski K, Johnson, BE, Cantley, LC. ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proc Natl Acad Sci USA. 2005 Mar 8; 102(10):3788-93. PubMed Link Johannessen CM, Reczek EE, James MF, Brems H, Legius E, Cichowski K. The NF1 tumor suppressor critically regulates TSC2 and mTOR. Proc Natl Acad Sci USA. 2005 Jun 14; 102(24):8573-8. PubMed Link Courtois-Cox S, Williams SMG, Reczek EE, Johnson BW, McGillicuddy LT, Johannessen CM, Hollstein PE, MacCollin M, Cichowski K. A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 2006; 10(6);459-472. PubMed Link Johanneson CM, Johnson BW, Williams SMG, Chan AW, Reczek EE, Lynch RC, Rioth MJ, McClatchey A, Ryeom S, Cichowski K. TORC1 is Essential for NF1-Associated Malignancies. Current Biology 2008; 8(Jan):56-62. Highlighted in Nature Reviews Cancer. Pubmed Link Reviews: Courtois-Cox S, Jones SL, Cichowski K. Many roads lead to oncogene-induced senescence. Oncogene 2008; 27: 2801-2809. Pubmed Link Cichowski K and Hahn WC. Unexpected Pieces to the Senescence Puzzle. Cell 2008; 133: 958-961. Pubmed Link |
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