Selected Beier Lab Publications

Shultz LD, Schweitzer PA, Rajan TV, Yi T, Ihle JN, Matthews RJ, Thomas ML, Beier DR. Mutations at the murine "motheaten" locus are within the hematopoietic cell protein tyrosine phosphatase (Hcph) gene. Cell 1993; 73: 1445-1454. PubMed Link

De Sanctis GT, Merchant M, Beier DR, Dredge RD, Grobholz JK, Martin TR, Lander ES, Drazen JM. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nature Genetics 1995; 11:150-154. PubMed Link

Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J, Beier DR. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism (SSCP) analysis. Genome Res.1997; 7:1085-93. PubMed Link

Neuhaus IM, Beier DR. Efficient localization of mutations by interval haplotype analysis. Mamm. Genome 1998; 9:150-154. PubMed Link

Förnzler D, Her H, Knapik EW, Clark M, Lehrach H, Postlethwait JM, Zon LI, Beier DR. Gene mapping in zebrafish using single-strand conformation polymorphism (SSCP) analysis. Genomics 1998; 51:216-22. PubMed Link

Iakoubova O, Dushkin H, Pacella L, and Beier DR. Genetic analysis of modifying loci on mouse chromosome 1 affecting severity in a model of recessive polycystic kidney disease. Physiological Genomics 1999, 1:101-105. PubMed Link

Kuida S and Beier DR. Genetic localization of interacting modifiers affecting severity in a murine model of polycystic kidney disease. Genome Research 2000, 10: 49-54. PubMed Link

Herron BJ, Lu W, Rao C, Liu S, Peters H, Bronson RT, Justice MJ, McDonald JD, Beier DR. Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nature Genetics 2002, 30:185-9. PubMed Link

Liu S, Lu W, Obara T, Kuida S, Lehoczky J, Dewar K, Drummond IA, Beier DR. A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Development. 2002,129:5839-46. PubMed Link

Rao C, Foernzler D, Loftus SK, Liu S, McPherson JD, Jungers KA, Apte SS, Pavan WJ and Beier, DR A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation. Development 2003, 130:4665. PubMed Link

Ackerman KG, Huang H, Grasemann H, Puma C, Singer JB, Hill AE, Lander E, Nadeau JH, Churchill GA, Drazen JM, Beier DR. Interacting genetic loci cause airway hyperresponsiveness. Physiological Genomics 2005, 21:105-11. PubMed Link

Herron BJ, Rao C, Liu S, Laprade L, Richardson JA, Olivieri E, Semsarian C, Millar SE, Stubbs L, Beier DR. A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice. Human Molecular Genetics 2005, 14:667-77. PubMed Link

Ackerman, K, Herron BJ, Vargas S, Huang H, Kochilas L, Rao C, Pober P, Babiuk R, Epstein J, Greer J, Beier DR. Fog2 is required for Normal Diaphragm and Lung Development in Mice and Man. PLoS Genetics, 2005, 1:58-65. PubMed Link

Moran JL, Bolton AD, Tran PV, Brown A, Dwyer ND, Manning DK, Li C, Montgomery K, Siepka SM, Vitaterna MH, Takahashi JS, Wiltshire T, Kwiatkowski DJ, Kucherlapati R, Beier DR. Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse. Genome Research, 2006, 16:436-40. PubMed Link

Moran JL, Qiu H, Turbe-Doan A, Yun Y, Boeglin WE, Brash AR, Beier DR. A mouse mutation in the 12R-lipoxygenase, Alox12b, disrupts formation of the epidermal permeability barrier. J Inv Derm. 2007, 127:1893-7. Pubmed Link

Tran PV, Haycraft CJ, Besschetnova TY, Turbe-Doan A, Stottmann RW, Herron BJ, Chesebro AL, Qiu H, Scherz PJ, Shah JV, Yoder BK, Beier DR. THM1 negatively modulates mouse Sonic Hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nature Genetics, 2008; 40: 403-410. Pubmed Link